Polyneuropathie 1 (LPN1) - Leonberger Searchterm Due to severe clinical phenotype

Due to severe clinical phenotype and symptoms

The symptoms become evident at 2 months of age

Schwierigkeiten beim Stehen und Gehen in einer geraden Linie

Dilated Cardiomyopathy (DCM) is an inherited hereditary disease that occurs in dogs

First clinical signs can be detected already at the age of 5 weeks (reduced cone ERG response)

Polyneuropathie 1 (LPN1) - Leonberger Searchterm Due to severe clinical phenotypeLeonberger Polyneuropathy 1 (LPN1) is a polyneuropathy condition (PN) that is associated with a mutation in ARHGEF10 gene. A loss of function of the gene may lead to the loss of proper nerve signalling. Polyneuropathy can display a wide range of age of onset and may appear due to the mutations in other genes (GJA9, NDRG1) with a different mode of inheritance. Clinical signs include generalized weakness, hypotonia, muscle atrophy secondary to