Lethale Akrodermatitis (LAD) All CMR1 is found in different

CMR1 is found in different dog breeds

The amount and distribution of pheomelanin may vary between individual dogs and between breeds

Die betroffenen Welpen müssen oft aufgrund schwerer Symptome eingeschläfert werden

exercise-induced tremor and muscle wasting characterize the disease

Inheritance: autosomal dominant (incomplete penetrance)

Lethale Akrodermatitis (LAD) All CMR1 is found in differentLethal acrodermatitis (LAD) is characterized by poor growth, immune deficiency, and skin lesions, especially at the paws. Affected puppies show characteristic skin lesions on the feet and on the face, diarrhoea, bronchopneumonia, and a failure to thrive. Coat color can be diluted in pigmented skin areas. LAD affected dogs are immunodeficient and frequently suffer from skin infections with Malassezia or Candida. They grow slower than their non affected