Kupfertoxikose (CT) - Labrador Retriever option-set-443684-checkbox-1 repeated formation of subcutaneous hematomas

repeated formation of subcutaneous hematomas and unexplained lameness since birth

thickening of the base of the tongue

caused by mutations in FVIII gene

die zu multifokalen Bereichen von äußerer Netzhautatrophie fortschreiten

die schließlich zu Arthropathie führen können

Kupfertoxikose (CT) - Labrador Retriever option-set-443684-checkbox-1 repeated formation of subcutaneous hematomasCopper metabolism disorders are genetic disorders of copper metabolism in the liver caused by mutations in two genes that code copper transporters ATP7A and ATP7B. The ATP7A transporter is crucial for copper transport from fibroblasts into the liver and the ATP7B is crucial for copper export from the liver. Mutations in the ATP7A result in defective ATP7A transporter so the copper cannot be properly exported from fibroblasts and imported into the