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Routine B12 monitoring is not mandated for tirzepatide, but baseline and periodic testing should be considered for high-risk patients, including those over 65, on concurrent metformin, with gastrointestinal disorders, or experiencing symptoms such as fatigue, neuropathy, or cognitive changes
Nausea is common during the first few weeks and typically diminishes over time
11 , e1004878 (2015)
They also play a key role in identifying mood changes, visual symptoms, or signs of dehydration that should trigger prescriber review
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