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In monotherapy trials with semaglutide oral tablets for T2DM, severe hypoglycemia (requiring the assistance of another person) was reported in 1% of patients receiving the 7 mg tablets and 0% of patients receiving the 14 mg tablets or placebo

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A typical Retatrutide titration might progress as: 1 mg weeks 1-4, 2 mg weeks 5-8, 4 mg weeks 9-12, 8 mg weeks 13-16, and 12 mg weeks 17 onward

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