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GLP-1 agonists suppress appetite by: Acting on the hypothalamus, the brain region that regulates hunger

Choose bland, easy to digest foods such as oatmeal, toast, rice, chicken, eggs, and steamed vegetables

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61 Activation of GLP-1 and GIP receptors stimulates insulin secretion from pancreatic beta cells in response to postprandial elevation in plasma glucose, and this effect is markedly attenuated under normoglycemic conditions, thereby mitigating the risk of hypoglycemia associated with GLP-1RAs therapy

For each specific gene knockdown, three forms of siRNAs were included, and an unrelated, scrambled siRNA without any match in human genomic sequence was used as a control