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see Methods for more detail) 25,26

31,35 The associated risk of developing dementia in diabetic patients who use GLP-1 RAs appears to be relatively low and is likely attributed to their effects on cerebral glucose metabolism

2 Molecular mechanisms of GLP-1 Action 2.1 GLP-1 Receptor structure and signalling The GLP-1 receptor (GLP-1R), a G-protein-coupled receptor, activates a complicated signalling cascade upon the interaction of GLP-1 (Fig