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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway

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To explore the effects of ATP metabolism on the synthesis of GSH, enzymes ( Sc ADK1, Pp ADK1, Vs VHB) of the ATP-related metabolic pathway and the energy co-substrate sodium citrate were taken into account