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a total of 21 patients had prior cholecystectomy to MBS [the median time between cholecystectomy and MBS was 15.9 months] and 8 patients who had undergone cholecystectomy after MBS [the median time between MBS and cholecystectomy was 63.4 months]), and the remaining patients, including those who had undergone cholecystectomy after diagnosis of PBH ( n = 7), were allocated to the Without prior cholecystectomy at PBH diagnosis group ( n = 102)

Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects

The triple-receptor design ensures multiple metabolic pathways are engaged regardless of starting composition, which is one reason the medication produces such consistent results across diverse body types

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Pharmacological Treatment of Obesity in Older Adults