Ans: Yes, they can, especially if underlying causes like sun exposure, poor sleep, or genetics are not managed
However, a small percentage of the population may still encounter problems from chronic acetaminophen usage or high doses
For example, Legionella pneumophila secretes the effector SdhA, which maintains mitochondrial integrity and limits mtDNA leakage, helping the bacterium to avoid immune hyperactivation ( Beyond the cGAS-STING and NLRP3 inflammasome pathways, mtDNA also serves as a ligand for endosomal TLR9, which recognizes unmethylated CpG motifs in bacterial and mitochondrial DNA (Tripathi et al., 2023)
Procalcitonin-guided use of antibiotics for lower respiratory tract infection
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