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While vitamin B12 deficiency is rarely a direct sign of cancer, unexplained or severe cases should always be medically evaluated
Published human trials report minimal adverse events at doses ranging from 50mg to 100mg daily over 12 weeks, with the most common findings being mild gastrointestinal discomfort (812% of participants) and transient headache (57%)
As a result, a deficiency in B12 has been linked to symptoms of depression, anxiety, and irritability
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