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Impact of Coverage of GLP-1 Drugs for Obesity on Medicare Expenditure s Source: JAMA Health Forum Hwang, April 25, 2025 Researchers in JAMA Health Forum used a microsimulation model to assess the likely financial results of Medicare covering GLP-1 drugs for obesity

Most likely, this is a result of misclassification of prevalent GLP-1 RA users as incident users, which may be the case for patients who receive prescriptions from pharmacies and hospitals not included in the LRx country-specific databases and who subsequently switch to those that are included

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10.1038/ncomms4672 31 KonecnyG

The detailed guide on retatrutide dosing after high-dose tirzepatide explains the pharmacological reasoning behind this conservative approach