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5 ROS can trigger ion channel opening, lipid peroxidation, protein modification, DNA oxidation, resulting in damage to cell structure and function, and even leading to cell apoptosis

In terms of mechanism, two key pathways are mainly responsible for activating apoptosis: the intrinsic pathway (mitochondria-mediated pathway) and the extrinsic pathway (death receptor-mediated pathway) (101, 102)

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