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Diabetologia (2025).

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

2) Engagement is linked to longer medication program persistence and stronger renewal In a separate January 2026 analysis focused on persistence, members in the top quartile of engagement were, on average, on a GLP-1 medication program for over twice as long (2.2x) within the first 12 months as those in the bottom quartile