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93 TakahashiT.SonobeM.MenjuT.NakayamaE.MinoN.IwakiriS.et al (2010)

Ultraviolet rays interact with these bonds to form free radicals, which then react further with oxygen in the atmosphere, producing carbonyl groups in the main chain

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There could be several reasons for the failure of these clinical trials: (1) Moderately positive results from animal studies with presymptomatic ALS mice do not necessarily translate into successful clinical trials when the same compound is given to patients with advanced stages of ALS