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as initiated) analyses, initiation of a GLP-1 receptor agonist was associated with a reduced risk of several incident SUDs (fig 3, fig 4, and supplementary table S6), including disorders related to alcohol use (hazard ratio 0.82 (95% CI 0.78 to 0.85), NRD per 1000 people 5.57 (6.61 to 4.53)), cannabis use (0.86 (0.81 to 0.90), NRD 2.25 (3.00 to 1.50)), cocaine use (0.80 (0.72 to 0.88), NRD 0.97 (1.37 to 0.57)), nicotine use (0.80 (0.74 to 0.87), NRD 1.64 (2.19 to 1.09)), and opioids use (0.75 (0.67 to 0.85), NRD 0.86 (1.19 to 0.52)), and other SUDs (0.87 (0.81 to 0.94), NRD 1.12 (1.68 to 0.55))

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Analytical Method & Instrumentation Standard:ICP-MS per ICH Q3D(R2) / USP Instrument:Agilent 7900 ICP-MS (SN: JP71586) with He collision mode Sample Preparation:Closed-vessel microwave digestion (CEM MARS 6): 52.1 mg + 5 mL HNO (suprapure) + 1 mL HO (30%) Digestion Program:Ramp 20 min 200C, hold 15 min, cool to RT, dilute to 50.0 mL (Milli-Q) Calibration:Multi-element std (NIST SRM 3100 series), 5-point external cal

These findings, as the researchers admit, are based on a very small sample size