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Negative effects Despite its beneficial properties, durian also comes with potential downsides, particularly when consumed in excess
Of the 846 ligand-regulated phosphosites (categories I and II), 49 sites were equally upregulated (category I-A) and 288 sites were equally downregulated (category II-A) in both WT-IR and L973F-IR cells in response to ligand stimulation (up- or downregulation of these sites was not significantly changed between these 2 cell lines)
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It was originally FDA-approved as Ozempic in 2017 to treat adults with type 2 diabetes
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