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Here, we addressed our mechanistic models experimentally using ScGrx7 as a reference enzyme 11,12,18
Different GLP-1 receptor agonists have varying pharmacokinetic profiles, receptor binding affinities, and dosing schedules
Cells were centrifuged and the supernatant collected
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GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others
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