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Goldstein at GWU and the Sosne/Kleinman collaboration for TB-500 and full T4) within separate preclinical model systems
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Key areas of investigation include modulation of the nitric oxide (NO) system through interaction with NOS isoforms, upregulation of growth factor receptors (including VEGFR2 and EGF receptor systems), and engagement of the FAK-paxillin signaling cascade associated with cell migration and adhesion
These include: Regulation of growth factor signaling Influence on nitric oxide (NO) pathways Interaction with angiogenesis-related processes Modulation of inflammatory responses These mechanisms are based primarily on experimental studies and continue to be investigated
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& Randall, G
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