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To provide better solutions for human health, research is needed to identify which constituents of whole foods (e.g., vitamins, minerals, phytonutrients) are primarily responsible for the synergistic effects seen in the host

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These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)

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