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A 2025 systematic review and meta-analysis published in Obesity Reviews analyzed eight randomized controlled trials that included participants with a BMI of 27 or higher (N=2,372) who had been on GLP-1 receptor agonist therapy and then stopped
Portal and email responses arrive eventually, but the quality was inconsistent during our testing
Side effects may include nausea, vomiting, diarrhea, constipation, and stomach pain, most are mild and decrease over time as dosing is titrated
For GLP-1 agonists, step therapy is much less commonly used as a utilization management tool, with fewer than 1 in 4 Marketplace plans requiring step therapy for each of the drugs included in this analysis
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