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Modulating ros to overcome multidrug resistance in cancer

One of the central regulatory pathway in redox balance is the Kelch-like ECH-Associating protein 1 (Keap1)nuclear factor erythroid 2 related factor 2 (Nrf2)antioxidant response element (ARE) pathway, which upregulates biosynthesis of antioxidant proteins, including antioxidant enzymes such as heme oxygenase-1 (HO-1), glutathione S -transferase, NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione reductase (GR), Trx-R, CAT, and SOD, but also nonenzymatic antioxidant proteins, e.g., Trx or anti-apoptotic proteins from Bcl-2 family 64

METHODS: The study enrolled 49 adult patients with a diagnosis of mushroom poisoning according to clinical findings and 49 healthy volunteers as the control group

It was unrealistic to expect them to respond candidly to questions put to them, especially by interviewers identified with the government, during the emergency

doi:10.1001/jamaoncol.2023.5573