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Shiraishi and colleagues demonstrated upregulation of alternatively activated macrophage-related molecules, such as IL-10, CD163, and CD204 in human monocyte-derived macrophage by GLP-1 [95]

That may give her unique insight into coping with ubiquitous weight-loss messaging, but she still uses multiple strategies herself

J Pediatr 1982;101:782-5

However, the risk of hypoglycaemia increases when Ozempic is used with insulin or sulfonylureas, which may require dose adjustments of these medications

My Take: Curious and Open Where I land: The biology supports the idea Some data supports the idea Safety at low doses is excellent Off-label is normalwhen done responsibly Placebo could explain somebut not allreported benefits If you try it, get baseline labs (fasting glucose, HbA1c, hsCRP, liver function tests) and a DEXA scan