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Trim37 maintains PGC fate by inhibiting somatic transition To investigate the fate of PGCs in Trim37 knockout embryos, we first evaluated whether Trim37 deficiency causes apoptosis in PGCs by cleaved caspase-3 staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay
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An intramolecular disulfide bridge in the receptor-binding domain of the SARS-CoV-2 spike protein between Cys-488 and Cys-480, considered to be important for ACE2-binding, results directly inhibited by NAC and GSH and these compounds could be used effectively against SARS-CoV-2 cell viral entry and infection (Murae et al., 2022)
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