After treatment with LDL-DHA nanoparticles, rat and human HCC cells underwent obvious lipid peroxidation, GSH depletion, and GPX4 inactivation before cell death, which ultimately proved to be ferroptosis 37
Additionally, with combination therapy as opposed to metformin, showed lower levels of fasting glucose, oral glucose tolerance test (OGTT) 2-h glucose, and OGTT 2-h insulin
Biological activity duration: Despite the short plasma half-life, downstream effects on telomerase expression and pineal regulation persist substantially longer (days to weeks) consistent with Epithalon acting as a signaling molecule triggering longer-lived transcriptional changes rather than direct dose-response activity
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International Journal of Pharmaceutical Sciences