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14 Two therapeutic strategies currently exist to overcome the short half-life of incretin hormones and pharmacologically augment the incretin effect: 1) inject GLP-1 receptor agonists that are resistant to degradation by the DPP-4 enzyme and 2) orally administer DPP-4 inhibitors that delay the enzymatic degradation of naturally secreted incretin hormones ( Figure 2 )

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SEMA, como tratamiento de la obesidad, ha mostrado efectos nefroprotectores con disminucin del 22% del objetivo renal compuesto en el estudio SELECT33 en pacientes sin diabetes, abogando por la utilidad de SEMA en el tratamiento del sndrome cardio-reno-metablico