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Secondary clinical endpoints included mean daily insulin dose, change in glycated hemoglobin, percentage of time in the target glucose range, and clinically relevant hypoglycemic events
Conclusions These findings identify disrupted GSH homeostasis and inflammatory activation as metabolic features associated with symptomatic TTR-V30M amyloidosis in vivo, supporting a link between redox imbalance and disease manifestation
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Patients with pre-existing gastroparesis, significant gastrointestinal disease, or previous gastric surgery require particularly careful monitoring and may benefit from gastroenterology consultation before initiating GLP-1 agonist therapy
Retatrutide, an innovative agent undergoing Phase III trials for obesity, T2DM, and non-alcoholic fatty liver disease, has demonstrated encouraging outcomes
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