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The 0.2 mg SAR425899 dose was the highest safe dose tested so far in humans and considered the target dose for late stage clinical development

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Blood samples were collected by venipuncture in Vacutainer CPT Mononuclear Cell Preparation Tubes (BD, Franklin Lakes, NJ) with sodium heparin, immediately placed in ice water, and then centrifuged at 2,000 g at 4C for 10 min

Individuals with higher baseline HbA1c levels or greater insulin resistance may experience more dramatic improvements in blood glucose control, though it may take longer to achieve target levels

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