semaglutide and local anesthesia Ozempic sedation dentistry: A cause for concern? semaglutide and local anesthesia Semaglutide

Nencioni A, Caffa I, Cortellino S, Longo VD

Surgery 179 , 108943 (2025)

This distinction matters when you're comparing a compounded semaglutide preparation at $199/month to an FDA-approved Wegovy injection at roughly $1,300+ per month retail

The FDA proposed to exclude semaglutide (Wegovy, Ozempic), tirzepatide (Zepbound, Mounjaro), and liraglutide (Saxenda, Victoza), popular glucagon-like peptide-1 (GLP-1) medications, from the 503B bulk list, citing a lack of clinical need for outsourcing facilities to compound these medications from bulk drug substances

Compounded Semaglutide: Cost and Availability PlexusDx offers compounded semaglutide injections at $189/mo month-to-month, or from $149/mo on the 6-month plan, making GLP-1 therapy accessible without insurance coverage