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Recent studies of isolated L-cells (95) and a L-cell derived cell line, GLUTag cells, have shown stimulation of GLP-1 secretion by glucose acting to inhibit K+ channels as in islet beta cells, by activation of the SGLT-1 transporter leading to depolarization (91), or activation of sweet taste receptors (T1R2 / T1R3) which activate Gq and PLC
However, most mechanistic evidence derives from experimental and ex vivo studies, whereas human data remain largely associative
Ammonia derived from glutaminolysis is a diffusible regulator of autophagy
The MEGASTROKE project received funding from sources specified at Data on glycemic traits have been contributed by MAGIC investigators and have been downloaded from www.magicinvestigators.org
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