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Retatrutide acts as a triple incretin receptor agonist, simultaneously activating three distinct receptors: GLP-1 receptors stimulating insulin secretion in a glucose-dependent manner, slowing gastric emptying, and reducing appetite GIP receptors enhancing insulin release and potentially improving fat metabolism Glucagon receptors increasing energy expenditure and promoting fat breakdown in the liver This multi-receptor activity produces pronounced effects on body weight, blood glucose, lipid metabolism, and hepatic fat

"Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes (SUSTAIN 2)"

Optimizing outcomes with Zepbound requires a comprehensive approach integrating pharmacotherapy with evidence-based lifestyle modifications

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