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Taking unplanned breaks often leads to rapid weight regain and may require dose rebuilding, which risks side effects

The authors argue that this off-label use exposes deeper tensions between medical innovation, body image ideals, and the social meanings attached to thinness, and explicitly ask whether such use should be considered an abuse of medical technology or a rational adaptation to weight-stigmatizing environments

With regard to kidney protection, in the doxorubicin (DOX) induced acute nephrotoxicity rat models, it was found that the treatment with L-theanine could attenuate the decrease of creatinine clearance, inhibit the production of lipid peroxidation in the kidney, and inhibit the reduction of glutathione content and SOD activity after DOX administration (90)

PMID 16864745

Typically, the urine test is best done 1 week after a missed period as before this time the accuracy is limited