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DEXA substudies across the class suggest somewhere between a quarter and a third of the loss can be lean mass, and the early retatrutide figure sits at the high end of that range, with the usual caveats about what DEXA actually measures

Researchers who compare retatrutide to other GLP-1 agonists will notice that the tirzepatide dosage chart in units follows a similar volume-based logic, just at different concentrations and dose levels

Aim for the NHS-recommended 6-8 glasses (around 2 litres) of fluid daily

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