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It is the only GHRH analog with FDA-recognized studies specifically demonstrating its ability to reduce visceral adipose tissue (VAT) the dangerous fat that surrounds abdominal organs and is associated with cardiovascular disease, insulin resistance, and metabolic syndrome

The Endocrine Society's 2023 obesity pharmacotherapy guidelines note that dose reduction or extended titration intervals are preferable to full discontinuation when side effects are manageable [11]

Similarly, dysfunction of T2R9 due to a single nucleotide polymorphism is associated with higher blood glucose and insulin responses to an oral glucose tolerance test in Amish individuals with and without type 2 diabetes (38)

In the cholesterol biosynthesis pathway, expression of genes such as lanosterol synthase ( Lss ), cytochrome P450, family 51 ( Cyp51 ), NAD(P) dependent steroid dehydrogenase-like ( Nsdhl ) and 7-dehydrocholesterol reductase ( Dhcr7 ) were decreased