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Dichloroacetate Dichloroacetate (DCA), a product of water chlorination, is considered for the treatment of several disorders including genetic mitochondrial diseases and some hyperproliferative conditions 82
For this reason, a remarkable number of inhibitors for GSTs have been synthesized as well as GSH analogues with better specificities and reduced toxicities 69,87
Paez PL, Becerra MC, Albesa I
The former variant, which affects gene splicing ( Figure 4 Table 1 GSS variations in Chinese patients with glutathione synthetase deficiency (GSSD)