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Clinical trials show that side effects become less frequent and less intense with continued treatment over 612 months

Methylene blue is generally safe when used under medical supervision

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Briefly, these studies revealed that DSePA treatment (at concentrations which are non-toxic for normal cells) inhibited the growth of lung cancer cells by causing reductive stress (marked by the increase in the levels of GSH and GPx) followed by mitochondrial and endoplasmic reticulum-dependent apoptosis [92]