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Glutathione, or ?-glutamyl-cysteinylglycine (GSH), is an important molecule that is produced within the body and is responsible for preventing lipid and protein oxidation, as well as for detoxifying hydrogen peroxide (H2O2)
10.1146/annurev-pathmechdis-012419-032711 19 ChavezJ
United States Pharmacopeia
In IPF, GSH levels are significantly reduced, contributing to a pro-oxidant environment that promotes fibroblast proliferation and ECM accumulation [120]
Second, repeated failures in well-designed human studies, despite adequate exposure and appropriate endpoints, suggest that preclinical models may not translate meaningfully into human physiology
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