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After we think in most of the mouse liver resection, the stress as a result of the surgery, peripheral fat mobilization and serum ALT, AST causes residual liver cells increased burden, gathered a large number of lipid in liver cell formation of lipid droplets, the lipid on the one hand, can give a short period through the beta oxidation liver regeneration process that require large amounts of energy to provide energy, In contrast, excessive accumulation of lipid droplets will cause aseptic inflammation to hepatocytes and damage liver function, which is a double-edged sword

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Since then, few patients discontinued setmelanotide due to objections over pigment changes