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[10] In the SURMOUNT-1 trial, patients with obesity achieved average weight reductions of approximately 15-21% of body weight over 72 weeks, alongside improvements in cardiovascular risk factors including blood pressure and lipid profiles, though cardiovascular outcome benefits have not yet been established
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Pilot clinical studies and case reports describe nausea in 65% of subjects at doses above 0,5 mg (resolution 2-4 h post-injection), flushing in 55%, transient increases in blood pressure and tachycardia in 40-60% of subjects, with peak acute effects occurring 90-120 minutes post-dose
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