It can lead to a better functioning metabolism, aids in weight management, and promotes nutrient utilization
Studies have found that GLP-1 mimetics can cross the blood-brain barrier and have neuroprotective effects, including reducing oxidative stress and chronic inflammatory responses in the brain
The non-specific melanocortin peptide agonist setmelanotide, which acts via the MC4R to inhibit food intake and produce weight loss, has been approved by the FDA for the treatment of proopiomelanocortin deficiency, leptin receptor deficiency and BardetBiedl syndrome
doi: 10.1016/s1357-2725(00)00087-x
The pathogenic link between PsA and T2DM is not yet fully understood, but inflammatory cytokines, particularly TNF and IL-17, are known to impair insulin signaling and promote insulin resistance [61]