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The prescribing information for semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) does not list alcohol as a contraindication, and no specific pharmacological drug-alcohol interaction has been established
[12] Coskun T, et al
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One placebo-controlled trial, called ATTAIN-MAINTAIN, followed adults who had previously completed the SURMOUNT-5 obesity trial, a randomized controlled study evaluating whether tirzepatide, the active ingredient in Zepbound, led to greater body weight reduction versus semaglutide in adults with obesity
Clinical causes include renal ischemiareperfusion (IR), nephrotoxic substances, sepsis, glomerulonephritis or interstitial nephritis, and extrarenal (such as prostatic hypertrophy) or intrarenal (such as kidney stones and thrombosis)
