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However, this test does not reflect the daily life of the patient [2]

Leptin-induced regulation of Bdnf mRNA expression is mediated by stimulation of an AKT/p300 HAT/H3 modification cascade The binding of leptin to LepRb activates three major signaling pathways, i.e., JAK2/STAT3, PI3K/AKT, and ERK pathways [68] (Fig

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The small number of outcome events in this study, which recorded only 70 events among 25,617 users of GLP-1RAs and had only 6,622 patients on GLP-1RAs remaining two years after cohort entry, has limited statistical power