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Bremelanotide is shown to be an agonist at melanocortin receptors such as MC3R and MC4R and is also considered to be a melanocyte-stimulating hormone that is an active metabolite of Melanotan II

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Rev Endocr Metab Disord 15(3):181187 van Bloemendaal L et al (2014) GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans

Its human GLP-1 backbone with 94% structural homology to native human GLP-1 produces minimal immunogenic response

The contradictory roles of HS suggest that further in-depth research is needed to explore the potential mechanisms and specific contexts in which HS exerts its effects, thereby providing new therapeutic targets for the treatment of breast cancer patients