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The 2021 and 2023 approvals of Novo Nordisks Wegovy and Eli Lillys Zepbound, respectively, ignited a GLP-1 market that is expected to exceed $100 billion in the next decade
Adipokines and insulin resistance
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Additional concerning features include bruising associated with systemic symptoms such as fever, unexplained fatigue, weight loss, night sweats, or enlarged lymph nodes, which could indicate hematological malignancy or other serious conditions
Signs of Serious Issues Contact your doctor immediately if your fatigue is accompanied by any of the following "red flag" symptoms: Severe or persistent vomiting or diarrhoea Dizziness, light-headedness, or fainting A persistent rapid heart rate Confusion or difficulty concentrating Signs of severe dehydration (e.g., dark urine, no urination for 8+ hours) Medication Review Large-scale semaglutide trials show GI side effects (nausea, diarrhoea, vomiting, constipation) are most frequent in the first weeks post-injection but are usually mild and resolve with time and dietary management
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