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Danuglipron and orforglipron are nonpeptide oral GLP-1R agonists in development that have shown encouraging safety and efficacy in glycemic control among patients with T2DM [179]
Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3 signaling
One vial holds both compounds at a fixed ratio (10/3 or 5/5)
4 mg per week Intermediate dose, with improved weight loss but still below the top-tier results
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