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Choi, J., Corder, N
Most available evidence comes from separate in vitro and in vivo studies that describe overlapping outcomes
In a Novo Nordisk funded study of 3,417 adults without diabetes and with a BMI of 30 or higher, or a BMI of 27 or higher with at least one obesity-related complication, participants achieved an average 20.4% weight loss with cagrilintidesemaglutide, compared with 3.0% with placebo 14
Furthermore, compelling evidence implicates this local, brainstem-derived GLP-1, rather than gut-derived GLP-1, as a principal modulator of physiological GLP-1R dependent signals that regulate appetite and body weight (Drucker and Asa, 1988
Yao C, Zhang F, Sun X, Shang D, He F, Li X, et al
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