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This influences the neuroendocrine regulation of hunger and satiety, leading to reduced food intake without conscious effort to limit calories

And the answer is more straightforward than the internet makes it look

GLP-1 receptor agonists are large protein molecules exceeding 3,000 Daltons in molecular weight, far above the 500 Dalton threshold for effective passive skin penetration

In the months that followed, everyone from former British Prime Minister Boris Johnson to billionaire entrepreneur Elon Musk acknowledged resorting to the medication to tamp down their appetites and slim down

Genetic factors, adherence to lifestyle modifications, baseline metabolic health, and age all influence where within this range a man falls