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For severe cases, a bigger dose might be given first, followed by smaller doses later
Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)
"The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying." Diabetes, Obesity and Metabolism
Mechanism of action: GLP-1 receptor agonists work through multiple physiological pathways
Gruber A, Horwood F, Sithole J, Ali NJ, Idris I
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