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Zealand is proposing to use glepaglutide to treat these patients, supporting its regulatory bid with data from one randomized, placebo-controlled late-stage trial

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Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems

We need studies on humans to establish its safety and efficacy