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Invasive liver macrophages led to chronic liver injury and fibrosis through HSC transdifferentiation and proliferation, while SCO inhibited HSC activation, downregulated macrophage infiltration, suppressed the secretion of NO, PGE2, iNOS and COX-2 in RAW 264.7 cells, and reduced the production of TNF-, IL-1 and IL-6 in RAW264.7 cells stimulated by LPS (17)

J Agric Food Chem 67:1004810058

Recommendations: A Collaborative Approach If you are considering or currently taking a GLP-1 inhibitor, especially if you have a pre-existing mental health condition, open communication with both your prescribing physician and your mental health provider is paramount

Important: Contrave should not be used if there is a history of seizures or eating disorders